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NaGalase Test

 

Why Test for NaGalase?

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NaGalase (alpha-N-acetylgalactosaminidase) is an enzyme that accumulates in serum of advanced cancer patients. NaGalase prevents the activation of the vitamin D-dependent protein Gc, thus preventing macrophage killing of cancer cells. The NaGalase test indicates the severity of the tumor burden in patients and can also be used to measure the effectiveness of treatment.

In addition to NaGalase, lactic acid can also be used to measure tumorburden within the patient. In cancer cells, cellular metabolism is solely based uponglycolysis with the end result being pyruvic acid and then conversion to lactic acid, asdescribed by the Warburg Effect. Lactic acid is secreted from the cancer cell where itcan be measured within serum.

Similarly to NaGalase and lactic acid, total IgG can be used to asses apatients tumor load and therapy effectiveness. It has been reported that several tumorsinduce IgG expression and it is postulated that IgG binding to a cancer cell prevents immune recognition and killing of the cancer cell.